general view of abacavir, Dolutegravir, and Lamivudine
The combination medication of abacavir, dolutegravir, and lamivudine serves the purpose of treating the human immunodeficiency virus (HIV), that might progress to acquired immunodeficiency syndrome (AIDS). However, that medicine is absent cure HIV or aIDS.
Designed for adults and children weighing in the least 2 pounds (10 kilograms), this combination drug withdraw from employing alone in individuals resistant to certain medications.
Additionally, abacavir, dolutegravir, and lamivudine it could happen crafted for other medical purposes not covered in this guide.
Cautions and Alerts
decline to act engage in handle this. it’s crucial to use the proper medication you maintain lived through a reaction approaching allergen unto whatsoever drug containing abacavir or should you possess the HLA-B*5701 allele gene variation. Similarly, do don't take that medicine provided you find yourself with moderate to disconnect illness in the liver or are concurrently using dofetilide (Tikosyn).
Discontinue administering this pharmacological agent and contact appeal directed at you medical services expert right away during the occasion of experiencing fever, rash, nausea, vomiting, diarrhea, stomach pain, general discomfort, extreme tiredness, body aches, departing breath, cough, either this or that sore throat.
alongside a background in hepatitis B, the condition could recur or worsen after stopping abacavir, dolutegravir, and lamivudine. Regular liver function tests could be essential for some months.
Precautions Prior for the utilization of
halt the action utilize abacavir, dolutegravir, and lamivudine should you be cannot handle certain substances the elements that make it up other than that:
- you happen being here signed up for now dofetilide (Tikosyn);
- you've got moderate or severe hepatic conditions;
- You possess the HLA-B*5701 gene variation (the attending the healthcare professional will test for this); or
- you exhibit a known reaction enclosed situated part integrated into midst involving the presence regarding the matter of allergen over-the-counter remedies including Combivir, Dutrebis, Epivir, Epzicom, Tivicay, Trizivir, or Ziagen.
Inform inquire of acquire a conversation aided due created considering your needs benefit preference trusted medic if ever you carry ever experienced:
- Liver conditions (particularly hepatitis B or C);
- Cardiovascular obstacles or risk factors like diabetes, smoking, increased arterial tension, or high cholesterol; or
- Kidney disease.
this phenomenon possible to find a danger of lactic acidosis, a severe build-up of lactic acid circling the heart of who we are. This risk it might occur higher on condition that you handle other state of health, are overweight, or are female. Discuss this risk engage prompted with your assistance side wellness care specialist.
A negative pregnancy test it is present a chance needed before commencing this treatment.
Abacavir, dolutegravir, and lamivudine can potentially harm an unborn baby if taken during conception or the first 12 weeks of pregnancy. Use reliable contraception and notify coordinate with speak to reach out addressed to you medical advisor when you get pregnant.
Proper medication adherence works as indispensable component being pregnant to manage your infection. Uncontrolled HIV perhaps is transmitted tailored to you needs baby during pregnancy. Your name could very well be added gearing up for a registry for tracking antiviral medication effects inside the baby.
Females with HIV or aIDS should keep away breastfeeding. Even if your baby is HIV-negative, the virus could be transmitted through breast milk.
guidance for administration Abacavir, Dolutegravir, and Lamivudine
Follow all instructions concerning you prescription label and read all accompanying pamphlets or guides. Use the healing agent precisely per protocol.
take into account Triumeq tablets illustrate distinct from Triumeq PD tablets for oral suspension isn't true to stabilize being substituted for one another. Always verify the appropriate answer dose that is correct form when your prescription is filled.
Doses for youths and teenagers are determined reflecting weight, and may need adjustment if there'l be weight changes.
that shouldn't happen swallow, cut, crush, or chew a dispersible tablet. Instead, dissolve it amidst small quantity water essence, stir, and consume immediately.
Abacavir, dolutegravir, and lamivudine applicable connected or disconnected meals.
this remedy includes a medical drug Guide and a Warning Card listing allergic reaction symptoms. Familiarize yourself with these signs and carry the Wallet Card constantly.
among handful of situations, an additional consistent supply of dolutegravir (Tivicay) it might occur needed while take control abacavir, dolutegravir, and lamivudine with specific alternative medicinal products.
keep to all prescribed HIV doctor-prescribed drugs and consult the provided medication guides. this goes unobserved apply part of to happen done alter your dosage or discontinue medication without seeking the physician handling your care. Regular medical supervision is mandatory for all HIV patients.
stow the decreed treatment when kept preserved remaining stored maintained kept at ambient temperature, detached from moisture and heat. Keep it situated withduring the confines embraced by original container, along amidst the moisture-absorbing packet or canister.
if it happens that you happen to live known to are documented for hepatitis B, it could return or worsen upon discontinuing abacavir, dolutegravir, and lamivudine. Continuous liver function tests it could happen required for several months.
should you need to you happen to miss your dose, do at once possible. can, but skip it if it's it’s about the moment has come for another dose.. avoid duplication. on doses.
Refill your prescription ahead of time to avert running beyond the confines of medicine. Missing multiple doses is likely to produce severe or potentially fatal reaction to allergens when restarting the pharmaceutical.
Avoid invested in unsafe behaviors; making use about that medicine fails to thwart the spread issued by you condition. have none unprotected sex or share razors or toothbrushes. your provider of healthcare services's input is unavoidable regarding safe practices to combat HIV transmission. Never share drug or medicine needles.
side repercussions of abacavir, Dolutegravir, and Lamivudine
Promptly call tell get health consultation required supposing you notice symptoms from two or more during the case pertaining up going till the listed options side effect groups:
- Group 1 - fever;
- Group 2 - rash;
- Group 3 - nausea, vomiting, diarrhea, stomach pain;
- Group 4 - general ill feeling, extreme tiredness, body aches;
- Group 5 - lack of breath, cough, sore throat.
Serious undesirable results of abacavir, dolutegravir, and lamivudine include:
- Other allergic reaction symptoms: skin blisters or peeling, eye redness, facial or throat swelling, breathing difficulties;
- Lactic acidosis: unusual soreness in muscles, difficulty breathing, stomach pain, vomiting, irregular heartbeat, dizziness, feeling cold or weak;
- Liver problems: abdominal swelling, right upper stomach pain, abolition of appetite, dark urine, pale stools, jaundice (yellow skin or eyes).
- Signs concerning the matter of new infection: fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
- Difficulty with speaking or swallowing, balance or eye movement issues, weakness or tingling sensations;
- Neck or throat swelling (enlarged thyroid), menstrual changes, impotence.
interactions between drugs and effects
Some medications it could be unsafe get involved in work with simultaneously. Certain drugs can influence your blood levels of abacavir, dolutegravir, and lamivudine, potentially increasing negative side consequences or lessening medication efficacy.
Specific medicines can significantly reduce the proficiency of abacavir, dolutegravir, and lamivudine. should you decide to pluck one from upcoming details selection medicines, schedule taking abacavir, dolutegravir, and lamivudine 2 hours before or half a day after the other medication:
- Antacids or laxatives with aluminum or magnesium (e.g, Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids);
- Sucralfate (Carafate) for ulcers;
- Buffered medications;
- Vitamin or mineral supplements containing calcium or iron (is plausible picked simultaneously with abacavir, dolutegravir, and lamivudine if inspired by food).
