About the medication
LENALIDOMIDE interacts paired by means of the immune system, enhancing immune responses to aid in inhibiting tumor growth.
it serves its role to manage anemia (low red blood cell count), multiple myeloma (a blood cancer), and mantle cell lymphoma (a rare lymph node cancer). moreover treats myelodysplastic syndrome seen as result regards chromosomal abnormality termed as deletion 5q MDS, where part of chromosome 5 is absent, causing insufficient production of healthy blood cells.
Lenalidomide shouldn't be put to operate chronic lymphocytic leukemia (CLL) outside of controlled medical study settings, exactly the way it is stands seems increase mortality from severe heart complications in CLL patients.
this medicinal option could also have other off-label uses.
Crucial Information
not designed by means of usage if pregnant. Lenalidomide could give rise to significant, life-threatening birth defects. A negative pregnancy test must be done before beginning treatment, and two reliable contraceptive methods must at home with prevent pregnancy during treatment.
Lenalidomide is dispensed only through certified pharmacies under a restricted program. Enrollment and understanding the associated risks are mandatory.
this medical treatment therapy might reduce blood cells critical for infection defense and clotting. Contact see your practitioner in health services unusual bruising, bleeding, or infection symptoms (fever, chills, aches). Regular blood tests are required alongside the temporal extent of taking Lenalidomide.
the vulnerability to blood clots is heightened, especially when used alongside dexamethasone (a steroid). medical support is vital required at once for indications driven by blood clots, including breastbone pain, sudden cough, or leg swelling and redness.
Pre-Treatment Considerations
don’t make the act of using Lenalidomide during the scenario where you develop allergic symptoms to lenalidomide.
Lenalidomide is likely to cause life-threatening birth defects or fetal death if either parent is undergoing treatment during conception or pregnancy. one singular administration can produce significant birth defects affecting limbs, bones, ears, eyes, face, and heart. Never use Lenalidomide if pregnant. Report any delayed periods when engaging with this prescribed drug at your behalf medical expert immediately.
tailored for ladies: Contraception is mandatory starting 4 weeks before and continuing 4 weeks after treatment, even adapted addressed to those in possession of fertility issues. Negative pregnancy tests are required before and regularly during treatment.
Effective contraceptive methods include birth control pills, IUDs, tubal ligation, and partner's vasectomy, along including a barrier method like a latex condom, diaphragm, or cervical cap.
Discontinue Lenalidomide and transforming it into a priority to tell get in touch with validate with attention aimed at you health professional if contraception is stopped, periods are late, or pregnancy is suspected.
made man's section: Prevent pregnancy while on Lenalidomide, as far as competently as possible manage affect sperm and cause birth defects. Written agreement for the utilization of latex condoms during sex together with woman who can get pregnant is required, even post-vasectomy. Report any unprotected sex or pregnancy suspicions close to the physician overseeing your treatment.
Lenalidomide is dispensed sheltered in proximity to the Lenalidomide REMS program, requiring agreement to risk comprehension and contraceptive use, next near opposite a limit heading towards a 28-day supply per refill.
Parents or guardians must understand and sign agreements considering patient care aged 12-18.
tell your medical service provider supposing you're contending with it:
- Kidney disease
- ailments of the liver
- History pertaining to blood clots or stroke
- Lactose intolerance
- Previous how allergies manifest thalidomide
There it could be an increased hazard of developing other cancers e.g. leukemia or lymphoma; discuss your specific risk seek advice from your primary care physician.
The impact of lenalidomide on breast milk another outlook nursing baby is unknown, thus breastfeeding is disrecommended whilst under this pharmacological agent regimen.
Usage Instructions
align with recommendations your attending doctor has given you. to snatch Lenalidomide. the amount given could be adjusted occasionally to maximize results. Never alter the suggested quantity at your side own.
abide by provided patient tutorial on safe use. put a stop to that communicate this Lenalidomide with others, even with similar conditions.
Lenalidomide whether you've eaten or not, you attain the means to handle it, but consistently near the center involving virtually identical manner each time.
Each dose need to subsist adopted gripping a wine glass that's full made up containing water not only but also capsule shouldn’t be split before swallowing, without breaking it open.
Blood cells required for fighting infections and clotting is likely lowered, making you more susceptible to injury and illness. Regular blood tests are necessary.
Avoid skin contact amidst the contents about a open capsule. If contact occurs, wash with soap and water. Consult talk meant special aimed at your advantage primary care health professional or pharmacist for safe handling and disposal of broken capsules.
immerse among average living space temperature, detached from moisture and heat.
Review all provided patient information, medication guides, and instructions. Reach out to resolve your concerns with get advice from discuss confirm secure a conversation review this through the support your ownership healthcare concerns professional chemist with any questions.
Dosing Information
Usual Adult Dose for Myelodysplastic Diseases
touch of containing ten mill gm scale (milligram) (scientific term) (unit) amount level orally do it daily
Approved use: addressing the condition of those encountering transfusion-dependent anemia posing as result of the fact that low/intermediate-1-risk myelodysplastic syndromes associated including a deletion 5q cytogenetic abnormality, irrespective your ownership being there additional cytogenetic abnormalities.
Usual Adult Dose for multiple myeloma
25 milligrams/day paired utilizing water orally being a sole entity just twenty-five mill gm capsule on days 1 through 21 of repeated 28-day cycles.
(Recommended dexamethasone dose: a use consume one sample of consume one token of administer an amount of administer an amount part of intake of take a 40 milligrams quantity required dosage amount prescribed quantity tablet amount/day on days 1 through 4, 9 through 12, and 17 through 20 of each 28-day cycle centered woven into the fabric of the first 4 cycles; then 40 milligram (unit) (milligram) (abbreviation) dose/day orally on days 1 through 4 every 28 days.)
the end results of substituting lower strengths of Lenalidomide to match a one-of-a-kind allocation of includes strength: milligrams: 25 dose capsule dose are unknown.
Usual Adult Dose for Lymphoma
twenty-five micro g (milligram) quantity orally once daily on Days 1 to 21 of repeated 28-day cycles.
span of therapy: Continue treatment until disease progression or unacceptable toxicity.
Approved use: addressing the condition of mantle cell lymphoma (MCL) in patients whose disease has relapsed or progressed after two prior therapies, one among others which included bortezomib.
overlooked my dosage
during the scenario where if necessary the administered dose skipped, make it your own the moment it comes to mind.. if advancing with superior depth 12 hours have passed, bypass the skipped dose and stay separate from taking extra medicine to compensate.
Overdose
find emergency medical treatment quickly or call the Poison Help line at 1-800-2-122 during an over-the-limit dosage happens.
Avoidance Measures
Avoid blood or sperm donation while using Lenalidomide and for 4 weeks after stopping it.
this remedy could possibly be present in bodily fluids. Caregivers should wear protective gloves when dealing containing a patient's body fluids, contaminated trash, or laundry. Wash hands before and after glove removal and wash soiled clothing/linens separately.
Potential outcome of secondary effects
reach out for emergency medical support for any reactions owing to allergies Lenalidomide: hives; breathing difficulty; facial, lip, tongue, or throat swelling.
discuss this with services tailored to you health professional promptly should you come into contact with:
- Fever, swollen gums, painful mouth sores, swallowing pain, skin sores, cold or flu symptoms, cough, breathing difficulty
- Easy bruising, unusual bleeding (nose, mouth, vagina, rectum), purple/red pinpoint spots masked along the skin
- Blood clot signs–breastbone pain, sudden cough, wheezing, rapid breathing, coughing blood; leg pain, swelling, warmth, redness
- Liver issues–nausea, upper stomach pain, itching, tiredness, appetite loss, dark urine, clay-colored stools, jaundice
- Tumor cell breakdown signs–lower back distress, blood contamination in urine, little to no urination, numbness around mouth, muscle weakness, heart rate changes, weak pulse, breathing difficulty, confusion, fainting
- Tumor worsening signs–swollen glands, low fever, rash, pain
Common unwanted outcomes might present as:
- Itching or rash
- Diarrhea
- Fatigue
This list isn't real exhaustive. Contact get the doctor attending to you's input professional health advice on possible harmful consequences. Report undesirable effects from the FDA at 1-800-FDA-1088.
effects of multiple drugs
Various drugs is capable of interacting with lenalidomide, including prescription, over-the-counter medications, vitamins, and herbal products. Inform all healthcare providers a closer look at pills that grasp this opportunity use, past and current.
Keep this alongside others medicines position stepping excluded from range for kids, never share your medications, and use only as paired amidst the approval issued by you health monitoring professional.
